The alcohol flush response, typically referred to as Asian Flush, is a situation characterised by facial redness after consuming alcohol. This response primarily stems from a genetic deficiency in aldehyde dehydrogenase 2 (ALDH2), an enzyme essential for metabolizing acetaldehyde, a poisonous byproduct of alcohol breakdown. When ALDH2 is poor, acetaldehyde accumulates within the physique, resulting in vasodilation and the attribute flushing, in addition to different signs like nausea, headache, and elevated coronary heart charge.
Whereas the genetic variant chargeable for ALDH2 deficiency is most prevalent in East Asian populations, it isn’t unique to them. The presence of this genetic mutation, no matter ethnicity, dictates whether or not a person experiences the alcohol flush response. Its significance lies in understanding particular person alcohol tolerance and related long-term well being dangers. Research have indicated that people with ALDH2 deficiency might face an elevated threat of esophageal most cancers with continued alcohol consumption.
